Applied Therapeutics, Inc.

545 Fifth Avenue, Suite 1400

New York, New York 10017


  May 17, 2023




Securities and Exchange Commission
Division of Corporation Finance
100 F Street NE
Washington, D.C. 20549

Attn:     Tim Buchmiller


Re:Applied Therapeutics, Inc.

Registration Statement on Form S-3 (File No. 333-271887)

Request for Acceleration of Effective Date


Ladies and Gentlemen:


We refer to the registration statement on Form S-3 (File No. 333-271887) (the “Registration Statement”), of Applied Therapeutics, Inc. (the “Company”).


In accordance with Rules 460 and 461 under the Securities Act of 1933, as amended, the Company hereby respectfully requests that the effectiveness of the Registration Statement be accelerated so that it may become effective at 4:00 p.m. (Eastern time) on Friday, May 19, 2023, or at such later time as the Company or its counsel may orally request via telephone call to the staff of the Division of Corporation Finance of the Securities and Exchange Commission.


Please call Michael J. Schwartz of Skadden, Arps, Slate, Meagher & Flom LLP, at (212) 735-3694, to confirm the effectiveness of the Registration Statement.



Very truly yours, 

  Applied Therapeutics, Inc.
  By: /s/ Shoshana Shendelman
    Name: Shoshana Shendelman
    Title: President and Chief Executive Officer
(Principal Executive Officer)