Applied Therapeutics to Present Data at ESC-HF Highlighting AT-001, a Novel, Potent and Selective Aldose Reductase Inhibitor for Treatment of Diabetic Cardiomyopathy
“We are excited to be presenting this data in a peer reviewed setting for the first time and are thrilled by the recognition from the congress and the clinical community,” said
Safety and Proof of
- AT-001 was well tolerated at all doses tested
Targetengagement was confirmed by potent aldose reductase (AR) inhibition as evidenced by significant reductions in sorbitol, a pharmacodynamic biomarker of AR activity
- AT-001 improved selectivity and affinity for AR resulted in potent AR inhibition
Beneficial Effects of AT-001, an Aldose Reductase Inhibitor, in Rodent Models of Diabetic Cardiomyopathy (
- AT-001 significantly reduced cardiac damage in a relevant mouse model of DbCM, confirming biological activity
- AT-001 normalized sorbitol levels, a biomarker of AR activity, demonstrating effective inhibition of AR
- Data evidences the role of AR inhibition in significantly reducing or preventing cardiac damage and supports clinical investigation of AT-001 in DbCM
About Diabetic Cardiomyopathy
Diabetic Cardiomyopathy (DbCM) is a rapidly progressing degenerative disorder of the heart muscle in people with diabetes. There are no approved therapies for this fatal condition, which affects 17 – 24 percent of people with diabetes, or approximately 77 million patients worldwide. Hyperglycemia, a symptom that characterizes diabetes, triggers the enzyme Aldose Reductase to convert excess glucose into sorbitol and fructose, both of which can lead to cell death in the heart muscle. When this happens, the heart fibroses, or “hardens,” such that the organ is unable to circulate blood through the body effectively. Approximately 25 percent of patients with DbCM progress to overt heart failure or death within 1.5 years of diagnosis.
AT-001 is an investigational oral, novel, potent Aldose Reductase inhibitor in clinical development for the treatment of Diabetic Cardiomyopathy. AT-001 has been studied in an investigational Phase 1/2 study in approximately 120 patients with type 2 diabetes, a subset of which had DbCM.
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Source: Applied Therapeutics